Oridonin Induces a Caspase-Independent But Mitochondria- and MAPK-Dependent Cell Death in the Murine Fibrosarcoma Cell Line L929
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منابع مشابه
Oridonin induces a caspase-independent but mitochondria- and MAPK-dependent cell death in the murine fibrosarcoma cell line L929.
Oridonin, an active component isolated from Rabdosia rubescences, has been reported to exhibit antitumor effects, but little is known about its molecular mechanisms of action. In this study, the growth-inhibitory activity of oridonin for L929 cells is in time- and dose-dependent manner. After treatment with various concentrations of oridonin for 12 h, the majority of L929 cells underwent apopto...
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Oridonin, an active component isolated from Rabdosia rubescences, has been reported to have antitumor effects. In this study, we compared the signal transduction pathways between TNFalpha-and oridonin-induced L929 cell death. Oridonin and TNFalpha initiated apoptotic morphologic changes, but DNA fragmentation was found in TNFalpha-treated L929 cells but not in oridonin-treated ones. The pan-cas...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2004
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.27.1527